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Published on: November 12, 2012
IRiS: construction of ARG networks at genomic scales
Asif Javed1, Marc Pybus, Marta Melé
1Computational Biology Center, IBM T J Watson Research, Yorktown Heights, NY 10598, USA.
Summary:
Given a set of extant haplotypes IRiS first detects high confidence recombination events in their shared genealogy. Next using the local sequence topology defined by each detected event, it integrates these recombinations into an ancestral recombination graph. While the current system has been calibrated for human population data, it is easily extendible to other species as well.
Availability:
IRiS (Identification of Recombinations in Sequences) binary files are available for non-commercial use in both Linux and Microsoft Windows, 32 and 64 bit environments from https://researcher.ibm.com/researcher/view_project.php?id = 2303
Contact:
parida@us.ibm.com.
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