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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Videos

Squamous cell carcinoma arising from chronic osteomyelitis.

Mohammed Alami1, Mustapha Mahfoud, Ahmed El Bardouni

  • 1Department of Orthopedic Surgery, CHU Ibn Sina Hospital, Rabat, Morocco. mmedalami@gmail.com

Acta Orthopaedica Et Traumatologica Turcica
|July 19, 2011
PubMed
Summary

Amputation is an effective treatment for squamous cell carcinoma secondary to chronic osteomyelitis. This study of 7 cases showed no recurrence or metastasis in amputated patients over five years.

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Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Dermatology

Background:

  • Squamous cell carcinoma can arise from chronic osteomyelitis.
  • This complication is rare but serious.

Purpose of the Study:

  • To present results from a retrospective study of 7 cases of squamous cell carcinoma secondary to chronic osteomyelitis.
  • To analyze cancerization time, localization, histopathology, and treatment outcomes.

Main Methods:

  • Retrospective analysis of 7 patients treated between 1993 and 2005.
  • Average patient age was 54.5 years (range: 38-71), with male predominance.
  • Data analyzed included time to cancerization, tumor site, histology, and treatment response.

Main Results:

  • Mean time to diagnosis of malignancy was 24.5 years (range: 9-40).
  • Carcinomas arose from tibia (4 cases), femur (2 cases), and humerus (1 case).
  • Five cases were well-differentiated squamous cell carcinoma with bone invasion; two were invasive.

Conclusions:

  • Amputation was performed in 6 out of 7 patients.
  • No local recurrence or metastasis was observed in the 6 amputated patients within five years.
  • Amputation is an effective treatment for squamous cell carcinoma secondary to chronic osteomyelitis.