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Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide
B K Sinha1, W M Antholine, B Kalyanaraman
1Biochemical Pharmacology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Biochimica Et Biophysica Acta
|November 14, 1990
Abstract:
The dihydroxy etoposide, a metabolite of the clinically active anticancer drug, VP-16, induced extensive DNA damage in the presence of copper ions. While superoxide dismutase was without any effect on the DNA damage, catalase and inhibitors of free hydroxyl radicals inhibited the DNA degradation, indicating that hydroxyl radicals were responsible for this drug-Cu-dependent DNA damage.