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Tandem Cycloisomerization/Suzuki Coupling of Arylethynyl MIDA Boronates
Julian M W Chan1, Giovanni W Amarante, F Dean Toste
1Department of Chemistry, University of California, Berkeley, California 94720, United States.
Abstract:
A tandem gold-catalyzed cycloisomerization/Suzuki cross coupling sequence involving arylethynyl-N-methyliminodiacetic acid boronates is described. Combining the mildness of homogeneous gold catalysis with the versatility of N-methyliminodiacetic acid (MIDA) boronates, this tandem two-step method enables the rapid assembly of various aryl-substituted heterocycles without having to isolate or purify any heterocyclic MIDA boronate intermediates. Another major advantage of this method is that a wide range of heterocycles bearing different aryl groups may be made from a single MIDA boronate alkyne precursor.
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