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Related Experiment Video

Updated: May 31, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Can breast cancer be prevented?

C G Kardinal¹, J T Cole

¹Section on Hematology and Oncology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA.

Ochsner Journal

|July 19, 2011

Summary

This summary is machine-generated.

Tamoxifen and raloxifene show promise in reducing breast cancer risk. The National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT) and the Multiple Outcomes of Raloxifene Evaluation (MORE) trial results led to the Study of Tamoxifen and Raloxifene (STAR) trial.

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Area of Science:

Oncology
Clinical Trials
Preventive Medicine

Background:

Breast cancer is a leading cause of cancer death in American women.
Previous trials like the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT) demonstrated tamoxifen's efficacy.
The Multiple Outcomes of Raloxifene Evaluation (MORE) trial indicated raloxifene's potential in reducing breast cancer risk.

Purpose of the Study:

To evaluate the efficacy of tamoxifen and raloxifene in breast cancer prevention.
To initiate a second-generation breast cancer prevention trial based on prior study outcomes.
To compare the effectiveness of tamoxifen and raloxifene in high-risk women.

Main Methods:

The National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT) randomized 13,388 women to tamoxifen or placebo for 5 years.
The Multiple Outcomes of Raloxifene Evaluation (MORE) trial assessed raloxifene for osteoporosis, with breast cancer risk reduction as a secondary outcome.
The Study of Tamoxifen and Raloxifene (STAR) trial was initiated to compare tamoxifen and raloxifene directly.

Main Results:

The BCPT trial resulted in a 49% reduction in invasive and a 50% reduction in noninvasive breast cancer.
Preliminary results from the MORE trial suggested a reduction in breast cancer risk for women taking raloxifene.
These findings paved the way for the STAR trial to further investigate these agents.

Conclusions:

Tamoxifen and raloxifene are effective agents for breast cancer risk reduction.
The STAR trial represents a significant advancement in breast cancer prevention research.
Continued research and clinical trials are crucial for optimizing breast cancer prevention strategies.