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Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
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Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Primary Healthcare Services01:30

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...

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Updated: May 31, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Major depression in primary care.

A M Rouchell1

  • 1Chairman, Department of Psychiatry, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA.

Ochsner Journal
|July 19, 2011
PubMed
Summary
This summary is machine-generated.

Major depression is common in primary care but often missed. Early diagnosis and treatment with counseling and medication improve outcomes for medically ill patients.

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

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Last Updated: May 31, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Primary care medicine
  • Psychiatry
  • Clinical diagnosis

Background:

  • Major depression is a significant clinical issue in primary care settings.
  • It is often underdiagnosed and undertreated, leading to increased morbidity and healthcare resource utilization.
  • Depression can be an early sign of underlying medical conditions.

Purpose of the Study:

  • To highlight the importance of diagnosing major depression in primary care.
  • To emphasize the need for thorough diagnostic work-ups.
  • To provide guidance on treatment strategies.

Main Methods:

  • Review of clinical presentation and diagnostic challenges of major depression in primary care.
  • Discussion of the impact of depression on medically ill patients.
  • Proposal of a treatment algorithm.

Main Results:

  • Major depression is prevalent and impacts medically ill patients significantly.
  • Effective treatment involves a combination of counseling and antidepressant medication.
  • A diagnostic and treatment algorithm can aid clinicians.

Conclusions:

  • Accurate diagnosis of major depression in primary care is crucial.
  • Integrated treatment approaches are most effective.
  • Clinical algorithms can support evidence-based management.