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Published on: February 21, 2018
Vasoactive intestinal peptide signaling axis in human leukemia
Glenn Paul Dorsam1, Keith Benton, Jarrett Failing
1Glenn Paul Dorsam, Keith Benton, Jarrett Failing, Department of Chemistry and Biochemistry, Center for Protease Research, North Dakota State University, Fargo, ND 58102, United States.
The vasoactive intestinal peptide (VIP) axis coordinates nervous and immune systems. This review explores VIP receptor roles in T cell leukemia, focusing on Ikaros regulation and therapeutic potential.
Area of Science:
- Immunology
- Neuroscience
- Oncology
Background:
- The vasoactive intestinal peptide (VIP) signaling axis is crucial for nervous and immune system communication.
- VIP and its receptors (VPAC1, VPAC2) regulate T cell functions like cell cycle arrest, apoptosis resistance, and immune cell trafficking.
- The VIP axis is implicated in various human cancers, including leukemia.
Purpose of the Study:
- To review current knowledge on VIP ligand and receptor expression in T cell leukemia.
- To discuss the regulation of VIP receptor expression by Ikaros in T lymphocytes.
- To explore the potential of the VIP signaling axis in leukemogenesis and its diagnostic/therapeutic implications.
Main Methods:
- Literature review of VIP signaling in T cell leukemia.
- Analysis of VIP and VPAC1/VPAC2 expression profiles in leukemia.
- Discussion of Ikaros's role in regulating VIP receptor expression.
Main Results:
- VIP and its receptors are expressed in T cell leukemia.
- Ikaros, an anti-leukemic transcription factor, influences VIP receptor expression in T cells.
- VIP receptor signatures on leukemic cells may offer diagnostic or therapeutic insights.
Conclusions:
- The VIP signaling axis plays a significant role in T cell leukemia.
- Understanding VIP receptor expression patterns could lead to novel therapeutic strategies.
- Further research is needed to fully elucidate the VIP axis's contribution to human leukemogenesis.
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