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Resonance light scattering as a powerful tool for sensitive detection of β-amyloid peptide by gold nanoparticle
Chengke Wang1, Dianjun Liu, Zhenxin Wang
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Chemical Communications (Cambridge, England)
|July 19, 2011
Abstract:
A novel biosensing strategy has been developed for sensitive detection of β-amyloid 1-42 (Aβ(1-42)) down to the ng mL(-1) level in both aqueous solution and diluted human plasma, which is based on measuring changes in resonance light scattering of streptavidin functionalized gold nanoparticles as a function of the concentration of Aβ(1-42) with a conventional spectrofluorometer.
