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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications
13:14

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Published on: April 14, 2015

Fluorescence upconversion microbarcodes for multiplexed biological detection: nucleic acid encoding.

Fan Zhang1, Qihui Shi, Yichi Zhang

  • 1Department of Chemistry, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P R China. zhang_fan@fudan.edu.cn.

Advanced Materials (Deerfield Beach, Fla.)
|July 19, 2011
PubMed
Summary
This summary is machine-generated.

Novel fluoride rare-earth-doped upconversion microbarcodes enable multiplexed signaling for nucleic acid detection. These advanced materials offer rapid, sensitive analysis with broad applications in clinical, food, and environmental testing.

Keywords:
encodingluminescencemicrobarcodesnanocrystalsupconversion

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Upconversion nanoparticles offer unique optical properties for sensing applications.
  • Multiplexed detection strategies are crucial for high-throughput analysis.
  • Nucleic acid and antigen detection are vital in diagnostics and monitoring.

Purpose of the Study:

  • To develop novel fluoride rare-earth-doped upconversion microbarcodes.
  • To demonstrate their utility in multiplexed signaling and nucleic acid encoding.
  • To explore their potential for rapid and sensitive detection assays.

Main Methods:

  • Synthesis of fluoride rare-earth-doped upconversion microbarcodes.
  • Characterization of their optical and structural properties.
  • Application in nucleic acid and antigen detection assays.

Main Results:

  • Successful development of upconversion microbarcodes.
  • Demonstration of effective multiplexed signaling capabilities.
  • Achieved rapid and sensitive detection of target analytes.

Conclusions:

  • Fluoride rare-earth-doped upconversion microbarcodes are a promising new material for advanced diagnostics.
  • These microbarcodes facilitate efficient multiplexed signaling and encoding.
  • Potential applications span clinical diagnostics, food safety, and environmental monitoring.