Related Experiment Video

Updated: May 31, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

[Evaluation of a new compact prothrombin time-international normalized ratio measurement device in pediatric

Y Maekawa1, T Sakawa, K Umezu

  • 1Division of Cardiovascular Surgery, Nagano Children's Hospital, Azumino, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|July 20, 2011
PubMed

Insights

The CoaguChek XS device accurately measures prothrombin time-international normalized ratio (PT-INR) in pediatric patients. This portable device is useful for managing children requiring long-term oral anticoagulation therapy.

Area of Science:

  • Pediatric Cardiology
  • Hematology
  • Medical Device Technology

Background:

  • Increasing need for long-term oral anticoagulation in pediatric patients due to extracardiac total cavo-pulmonary connection (TCPC) and valve surgery.
  • Evaluation of novel point-of-care devices for monitoring anticoagulation therapy in children.

Purpose of the Study:

  • To assess the accuracy and utility of the CoaguChek XS device for measuring PT-INR in a pediatric population.
  • To compare CoaguChek XS PT-INR results with a standard laboratory coagulation analyzer.

Main Methods:

  • Prospective study involving 71 pediatric patients.
  • Collection and analysis of 223 blood samples.
  • Comparison of PT-INR values obtained from CoaguChek XS with a laboratory-based coagulation analyzer.

Main Results:

  • CoaguChek XS demonstrated a significant correlation with laboratory-based results (r2 = 0.92, p < 0.01).
  • The regression analysis showed a strong linear relationship (y = 1.05x - 0.02), indicating high agreement.
  • The device provides reliable PT-INR measurements in pediatric samples.

Conclusions:

  • The CoaguChek XS is a valuable and accurate tool for monitoring PT-INR in pediatric patients.
  • Its use can facilitate effective management of oral anticoagulation in children.
  • The device supports efficient clinical decision-making in pediatric anticoagulation therapy.
Abstract

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...