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Published on: December 11, 2017
Benefit of specialized clinics for the treatment of patients with heart failure
Ghazaleh Gouya1, Alexandra Hammer, Marie Elhenicky
1Department of Clinical Pharmacology, Medical University Vienna, Austria. ghazaleh.gouya@meduniwien.ac.at
Insights
Specialized heart failure clinics improve care for newly referred patients, optimizing medication and quality of life. Long-term patients showed no additional benefit, suggesting focused initial intervention is key for heart failure (HF) management.
Area of Science:
- Cardiology
- Clinical Medicine
- Pharmacotherapy
Background:
- Current guidelines advocate specialized outpatient units for heart failure (HF) patient care.
- This study evaluates the benefit of specialized HF clinics for different patient referral timelines.
Purpose of the Study:
- To determine if all heart failure patients achieve equivalent benefits in specialized clinics.
- To compare outcomes for recently referred patients versus those in long-term care (>1 year).
Main Methods:
- Observational cohort study with 474 heart failure patients.
- Patients stratified into recently referred (130) and long-term care (344) groups.
- Data collected at baseline and 12-month follow-up.
Main Results:
- Recently referred patients showed significant pharmacotherapy enhancement (67%), NT-proBNP reduction, and improved quality of life.
- Long-term care patients exhibited no significant changes in these parameters.
- Hospitalization rates were higher in recently referred patients; all-cause mortality was similar between groups.
Conclusions:
- Specialized HF clinics optimize pharmacotherapy and improve quality of life and NT-proBNP levels in patients referred within 12 months.
- Maintenance therapy beyond this initial optimization period yields minimal additional benefit for chronic HF patients.
Background:
Current guidelines recommend special attention for heart failure (HF) patients in dedicated outpatient units.
Aims And Methods:
In this observational cohort study we sought to determine whether an equivalent benefit is achieved in all HF patients treated in specialized heart failure clinics. Patients were stratified to patients recently referred and those who already receiving long-term care (>1 year). Data were collected at baseline and after 12 months.
Results:
474 patients were prospectively observed. 130 subjects were recently referred and 344 subjects had received long-term care. During follow-up of recently referred patients, enhancement of neurohumoral pharmacotherapy was achieved in 67% (p<0.001), which was paralleled by a reduction in NT-proBNP (baseline 1779 pg/ml [range 458;4685]; after 12 months 668 pg/ml [range 167;1690]; p<0.001) and improvement in quality of life score, measured by the Minnesota Living with Heart Failure Questionnaire by 8 points [range 0;23]; (at baseline 34 points [range 16;59], and after 12 months 15 points [range 5;42]; p=0.04). In contrast, these parameters were unchanged in long-term care patients. Hospitalization for HF and other cardiovascular causes was higher in patients recently referred, and all-cause mortality was comparable in both groups.
Conclusions:
This comprehensive analysis of chronic HF patients treated in a specialized HF outpatient clinic confirmed the potential to optimize pharmacotherapy paralleled by improvements in quality of life and NT-proBNP levels in patients referred within the first 12 months. Prolonged management of HF patients after this optimization of maintenance therapy yields little additional benefit.
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