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Updated: May 30, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
Massive fetomaternal hemorrhage secondary to intrauterine intravascular transfusion
Yaël Levy-Zauberman1, Agnès Mailloux, Aminata Kane
1From the Department of Obstetrics and Gynecology and Centre National de Référence en Hémobiologie Périnatale, Hôpital Saint-Antoine, Paris, France; and Assistance Publique - Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
Background:
Small-volume fetomaternal hemorrhage is frequently observed after intrauterine transfusion. The Kleihauer-Betke test, the reference method for identifying fetomaternal hemorrhage, cannot be used after intrauterine transfusion, because the adult red blood cells used for transfusion cannot be distinguished from maternal red blood cells.
Case:
Massive fetomaternal hemorrhage secondary to intrauterine transfusion led to fetal hemorrhagic stroke. We used a method based on blood group identification in the maternal blood to confirm and to quantify fetomaternal hemorrhage.
Conclusion:
Fetal stroke may result from severe hypovolemia and low cerebral blood flow caused by fetomaternal hemorrhage, rather than from fetal anemia itself.
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