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Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

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Open trial of injectable risperidone for methamphetamine dependence.

Charles W Meredith1, Craig Jaffe, Monique Cherrier

  • 1From the Mental Health Service (CWM, JPR, CAM, EVY, AK, LCF, AMT, and AJS), Center of Excellence in Substance Abuse Treatment and Education (CAM, LCF, and AJS), VA Puget Sound Health Care System; and Department of Psychiatry and Behavioral Sciences (CWM, CJ, MC, LCF, AMT, and AJS), University of Washington, Seattle, WA.

Journal of Addiction Medicine
|July 20, 2011
PubMed
Summary
This summary is machine-generated.

Long-acting injectable risperidone significantly reduced methamphetamine use in an open trial. This treatment also showed potential benefits for verbal memory, warranting further investigation in controlled studies.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Methamphetamine (MA) dependence is a significant public health issue with limited pharmacotherapies.
  • Long-acting injectable formulations offer potential advantages for medication adherence in substance use disorders.

Purpose of the Study:

  • To assess the acceptability and tolerability of long-acting injectable risperidone for methamphetamine dependence.
  • To evaluate the efficacy of injectable risperidone in reducing MA use and its impact on neurocognitive function and psychiatric symptoms.

Main Methods:

  • An open-label trial involving 34 participants with MA dependence.
  • Participants received oral risperidone followed by 4 intramuscular injections of long-acting risperidone (25 mg) every 2 weeks.
  • Relapse prevention counseling was offered weekly.

Main Results:

  • Significant reduction in weekly methamphetamine use from a baseline average of 4.1 days to 1.0 day per week by week 8 (P < 0.001).
  • Verbal memory showed improvement at week 4 compared to baseline (P < 0.05).
  • No serious adverse events were reported; plasma levels were higher in abstinent participants.

Conclusions:

  • Injectable risperidone demonstrated potential in reducing methamphetamine use and improving verbal memory in this open trial.
  • The findings are limited by the open-label design and high dropout rate.
  • Further controlled trials are warranted to confirm risperidone's efficacy as a pharmacotherapy for MA dependence.