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Updated: May 30, 2026
02:20
Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors
Published on: February 9, 2024
Peri-ampullary mixed acinar-endocrine carcinoma
Ayman Soubra1, Walid Faraj, Jad Saab
1Department of Internal medicine, Oncology unit, American University of Beirut Medical Center, Beirut, Lebanon;
Rare Tumors
|July 20, 2011
Summary
Mixed acinar-endocrine carcinomas (MAEC) are rare pancreatic tumors. This case study details a patient with MAEC who experienced recurrence and metastasis despite successful initial surgery and chemotherapy.
Area of Science:
- Gastroenterology and Oncology
- Pancreatic Cancer Research
- Surgical Pathology
Background:
- Mixed acinar-endocrine carcinomas (MAEC) represent a rare subtype of pancreatic neoplasms.
- Periampullary tumors can present with varied clinical manifestations, including painless jaundice.
Observation:
- A patient with a periampullary tumor was diagnosed with MAEC.
- The initial treatment involved pancreaticoduodenectomy, achieving tumor-free margins and negative lymph nodes.
Findings:
- Despite curative-intent surgery, the patient developed local recurrence and liver metastasis within one year.
- Chemotherapy resulted in stable disease 30 months post-diagnosis, indicating a complex treatment response.
Implications:
- This case highlights the aggressive nature of MAEC and the challenges in achieving long-term remission.
- Further research into novel therapeutic strategies for advanced MAEC is warranted.
- Understanding recurrence patterns is crucial for optimizing patient management and follow-up protocols.
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