Related Experiment Video
Updated: Jan 13, 2026
03:32
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
1.5K
Primary gastric chorioadenocarcinoma: a needle in a haystack
Aditi Shastri1, Naval G Daver, Teresa G Hayes
1Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Rare Tumors
|July 20, 2011
Summary
Primary gastric chorioadenocarcinoma (PGC) is a rare cancer often mistaken for gastric adenocarcinoma. Elevated beta human chorionic gonadotrophin (Beta HCG) is a key indicator, aiding diagnosis and monitoring treatment response.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary gastric chorioadenocarcinoma (PGC) is an extremely rare gastric malignancy.
- It is frequently misdiagnosed as common gastric adenocarcinoma.
- Elevated serum beta human chorionic gonadotrophin (Beta HCG) is a hallmark of PGC.
Observation:
- A 44-year-old male presented with abdominal pain, weight loss, and elevated Beta HCG (23717.5 MIU/ML).
- CT scans revealed a gastric mass with liver metastases.
- Biopsy confirmed poorly differentiated adenocarcinoma with Beta HCG staining.
Findings:
- The patient was diagnosed with metastatic PGC and received chemotherapy (Bleomycin, Etoposide, Cisplatinum).
- Despite initial Beta HCG normalization, imaging showed disease progression.
- The patient developed pancytopenia, DIC, and expired 12 months post-presentation.
Implications:
- PGC exhibits characteristics of both adenocarcinoma and choriocarcinoma.
- Serum Beta HCG levels may be crucial for assessing treatment efficacy and detecting recurrence.
- Early diagnosis, curative resection, chemotherapy, and absence of metastases are vital for improved survival in PGC.
Related Concept Videos
01:27Gastritis-I: Introduction and Types
2.1K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
2.1K
01:17Gastritis-II: Pathophysiology
1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
01:23Gastritis III: Clinical Manifestations and Management
1.1K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.1K
01:21Barrett Esophagus-I: Introduction
604
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
604