The cholestyramine-induced decrease of PYY postprandial response is negatively correlated with fat mass in obese
A E Rigamonti1, M Resnik, E Compri
1University of Milan, Department of Medical Pharmacology, Milan, Italy. antonello.rigamonti@guest.unimi.it
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 20, 2011
Summary
Obese women showed altered peptide YY (PYY) response to a high-fat meal. Cholestyramine reduced PYY secretion, suggesting L cell dysfunction in obesity.
Area of Science:
- Endocrinology
- Gastroenterology
- Obesity Research
Background:
- Obesity is linked to reduced levels of peptide YY (PYY), a key appetite-regulating hormone.
- Fatty nutrients are potent stimulators of PYY release from gastrointestinal L cells.
- Cholestyramine, a bile salt adsorbent, can impact lipid digestion and absorption.
Purpose of the Study:
- To investigate the effect of cholestyramine on postprandial PYY secretion in obese women.
- To explore the relationship between body fat percentage, PYY response, and cholestyramine administration.
Main Methods:
- Eight obese women (BMI 47.3±3.3 kg/m2) received a high-fat meal with either cholestyramine or placebo.
- Plasma PYY levels were measured at multiple time points post-meal.
- Correlations between fat mass (FM%) and PYY changes were analyzed.
Main Results:
- Placebo administration led to a significant increase in postprandial PYY levels.
- Cholestyramine significantly blunted the PYY response at early post-meal time points (15, 30, 60 min).
- Higher FM% correlated with a reduced PYY increment after the meal and an increased PYY decrement with cholestyramine.
Conclusions:
- Obese individuals exhibit impaired PYY secretion in response to fatty meals.
- Cholestyramine administration further suppresses PYY release in obese women.
- Altered PYY response in obesity may stem from L cell insensitivity to lipid stimuli.
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