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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Motion-sensitized driven equilibrium for blood-suppressed T2* mapping.

Rexford D Newbould1, David R J Owen, Joseph Shalhoub

  • 1GSK Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom. rexford.newbould@gmail.com

Journal of Magnetic Resonance Imaging : JMRI
|July 20, 2011
PubMed
Summary

Motion-sensitized driven equilibrium (MSDE) preparation effectively suppresses blood signal in T2* mapping using spoiled gradient-echo sequences (SPGR). This allows for accurate T2* measurements of carotid plaques and liver without blood vessel interference.

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Medical Physics

Background:

  • T2* mapping is crucial for assessing carotid plaques and liver conditions.
  • Blood signal can confound T2* measurements in these tissues.
  • Existing methods struggle to effectively suppress blood signal.

Purpose of the Study:

  • To integrate motion-sensitized driven equilibrium (MSDE) preparation with multi-echo spoiled gradient-echo (SPGR) sequences.
  • To suppress blood signal intensity in T2* mapping of carotid plaques and liver.
  • To optimize sequence parameters for robust blood suppression.

Main Methods:

  • Analytical solutions of Bloch equations were used to optimize MSDE-SPGR parameters.
  • The sequence was implemented on a 3 Tesla scanner.
  • T2* maps were acquired from healthy livers and subjects with carotid plaques after optimization for blood suppression.

Main Results:

  • Simulations and experiments demonstrated an increased Ernst angle with MSDE-SPGR compared to pure SPGR.
  • Robust blood signal suppression was achieved in T2* maps of carotid plaques and liver.
  • Effective suppression required a field of speed (FOS) of 30 cm/s.

Conclusions:

  • MSDE preparation is a viable method for suppressing blood signal in SPGR sequences.
  • This technique enables accurate T2* mapping of tissues, free from confounding vascular signals.
  • MSDE-SPGR enhances the diagnostic utility of T2* mapping for carotid plaques and liver disease.