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Updated: May 30, 2026

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
Published on: July 28, 2022
Curvature instability in a chiral amphiphile self-assembly
Lior Ziserman1, Amram Mor, Daniel Harries
1Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Abstract:
We present the first experimental evidence for the morphological transition from twisted to helical ribbons in amphiphile aggregates. This transition, from structures possessing negative Gaussian curvature to helically curved structures, is shown to be directly linked to ribbon width. Time-resolved cryotransmission electron microscopy images of a peptidomimetic amphiphile further capture the dynamic transformation between the two geometries along a single ribbon unit. Quantitative analysis indicates that both ribbon width and pitch grow with ribbon maturation, maintaining a constant ratio.
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