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Inhibitory effects of three oleanolic acid glycosides from Achyranthes japonica on the complement classical pathway
Seil Jung1, Jai-Heon Lee, Young-Choon Lee
1Department of Urology, College of Medicine, Dong-A University, Busan, South Korea.
Abstract:
The present study evaluated the anticomplement effects of isolated compounds from Achyranthes japonica in the classical pathway of the complement system. Using column chromatography, three compounds: achyranthoside C dimethyl ester, achyranthoside C butyl dimethyl ester, and achyranthoside E dimethyl ester were isolated and evaluated for in vitro anticomplement activity. Achyranthoside C dimethyl ester showed the most potent inhibitory activity against the complement system, with 50% inhibitory concentrations (IC(50)) values of 26.2 μg/mL. This is the first report of anticomplement activity of isolated compounds from A. japonica.
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