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Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
ABO-incompatible kidney transplantation in children
Gunnar Tydén1, Gunilla Kumlien, Ulla B Berg
1Departments of Transplantation Surgery Transfusion Medicine Pediatrics, Karolinska University Hospital, Stockholm, Sweden. gunnar.tyden@karolinska.se
Pediatric Transplantation
|July 21, 2011
Summary
A novel protocol for ABO-incompatible kidney transplants uses antigen-specific immunoadsorption and rituximab. This method shows comparable success rates, renal function, and safety to ABO-compatible transplants, including in pediatric patients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Immunosuppression
Background:
- ABO-incompatible kidney transplantation is limited by anti-A/B antibodies.
- Traditional protocols involve non-specific plasma exchange and splenectomy, which have drawbacks.
Purpose of the Study:
- To introduce and evaluate a new protocol for safe ABO-incompatible kidney transplantation.
- To compare the outcomes of this new protocol with standard ABO-compatible transplantations.
Main Methods:
- Utilized antigen-specific immunoadsorption to remove anti-A/B antibodies.
- Administered rituximab to prevent antibody rebound, avoiding splenectomy.
- Transplanted sixty patients, including ten children, using the new protocol.
Main Results:
- The new protocol demonstrated successful transplantation in all sixty patients.
- No significant differences were observed in success rates between ABO-incompatible and ABO-compatible transplantations.
- Renal function and adverse event profiles were comparable across both transplantation types.
Conclusions:
- The developed protocol enables safe and effective ABO-incompatible kidney transplantation.
- This approach offers a viable alternative to ABO-compatible transplantation with similar outcomes.
- The protocol is effective in both adult and pediatric kidney transplant recipients.
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