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Extraosseous uptake with DPD (Teceos(®)).

Tore Bach-Gansmo¹, Trond V Bogsrud, Laila Holmboe

¹Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. bat@uus.no

Clinical Physiology and Functional Imaging

|July 21, 2011

Summary

This summary is machine-generated.

Unexplained intense uptake of bone-seeking agents in the heart and liver was observed in multiple patients. Investigations ruled out contamination and kit abnormalities, leaving the cause of this extraosseous uptake unknown.

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Area of Science:

Nuclear Medicine
Radiopharmacy

Background:

Unexplained intense extraosseous uptake of a technetium-labelled bone-seeking agent was observed in patients.
This phenomenon occurred in the heart and liver, prompting an investigation into its cause.

Purpose of the Study:

To investigate the cause of unexpected intense cardiac and liver uptake of a bone-seeking agent detected during bone scintigraphy.
To identify potential reasons for these findings, including kit abnormalities or contamination.

Main Methods:

Bone scintigraphy was performed using Teceos® after standard kit labeling.
Retrospective analysis of the radiopharmaceutical kit was conducted.
Patients were re-examined, and referring physicians were contacted; blood tests were also performed.

Main Results:

Intense cardiac uptake was recorded in at least ten patients, primarily older individuals.
One young patient exhibited massive liver uptake.
No abnormalities were found in the radiopharmaceutical kit's labeling or composition.

Conclusions:

The cause of the intense cardiac and liver uptake of the bone-seeking agent remains undetermined.
Potential causes like amyloidosis or myocardial infarction were considered but deemed improbable.
Further investigation is needed to elucidate the etiology of these unexpected findings.