Related Experiment Video
Updated: May 30, 2026
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report
Kristin Coners1, Scott E Woods, Michael Webb
1Bethesda Family Medicine Residency Program, 4411 Montgomery Road, Suite 200, Cincinnati, OH 45212, USA. Liverdoctor@yahoo.com.
Introduction:
We describe the case of a patient with small cell lung cancer and dual paraneoplastic syndromes involving adrenocorticotropic hormone and calcitonin. To the best of our knowledge, dual paraneoplastic syndromes involving these two hormones have not been previously reported in the literature.
Case Presentation:
A 74-year-old Caucasian woman presented with a left hilar mass and metastatic disease in the liver and right adrenal gland. The patient complained only of intermittent diarrhea. Her laboratory values exhibited metabolic alkalosis with hypokalemia, hypocalcemia, hypomagnesemia, hypophosphatemia, and hyperglycemia.
Conclusion:
We discuss the work-up and treatment of the patient's unusual laboratory presentation with two concurrent paraneoplastic syndromes.