Related Experiment Video
Updated: May 30, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
Published on: April 20, 2018
NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development
Silvia Cappello1, Pascale Monzo, Richard B Vallee
1Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. silvia.cappello@helmholtz-muenchen.de
Nuclear migration protein NudC is essential for neuronal migration during brain development. This study reveals its specific role in radial glial progenitor cells, highlighting its importance in neocorticogenesis.
Area of Science:
- Neuroscience
- Cell Biology
- Developmental Biology
Background:
- NudC is a conserved protein vital for nuclear migration in Aspergillus nidulans.
- NudC interacts with Lis1, a protein crucial for neuronal migration in mammals.
Purpose of the Study:
- To investigate the role of NudC in mammalian neuronal migration.
- To determine if NudC plays a part in neocorticogenesis.
Main Methods:
- In utero electroporation in embryonic rat brains.
- Expression of shRNAs, wild-type, and mutant NudC.
Main Results:
- NudC is required for neuronal migration during rat neocorticogenesis.
- NudC plays a specific role in apical nuclear migration in radial glial progenitor cells.
Conclusions:
- NudC is a novel gene involved in neuronal migration.
- NudC's function in interkinetic nuclear migration is linked to cytoplasmic dynein regulation.
Related Concept Videos
Cytoskeletal Coordination in Cell Migration
Neurulation
Cell Migration
Cell Migration

