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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Antibiotic prescriptions in French day-care centres: 1999-2008

Brigitte Dunais1, Christophe van Dijken, Pascale Bruno

  • 1Public Health Department, Centre Hospitalo-Universitaire de Nice, Nice, France. dunais.b@chu-nice.fr

Archives of Disease in Childhood
|July 21, 2011
PubMed

Insights

Antibiotic prescriptions for children in day-care centres dropped significantly after public health campaigns and pneumococcal vaccination. Further improvements in antibiotic selection and indications are needed.

Area of Science:

  • Pediatric infectious diseases
  • Public health interventions
  • Antimicrobial stewardship

Background:

  • Antibiotic resistance is a growing global concern.
  • Prudent antibiotic use in children is crucial for preventing resistance.
  • Day-care centres (DCCs) are settings with high rates of antibiotic prescribing.

Purpose of the Study:

  • To evaluate trends in antibiotic prescriptions among children attending DCCs.
  • To assess the impact of public health campaigns and pneumococcal conjugate vaccine (PCV) introduction on antibiotic use.
  • To analyze changes in antibiotic indications and types of antibiotics prescribed.

Main Methods:

  • Cross-sectional studies conducted in Alpes Maritimes, France, in 1999, 2004, and 2008.
  • Sample included children aged 3 months to 4 years attending DCCs.
  • Data collected on antibiotic treatments and indications in the preceding 3 months.

Main Results:

  • Proportion of children receiving antibiotics decreased from 58.5% in 1999 to 29.7% in 2008.
  • Number of treated episodes per child significantly dropped (p<0.00001).
  • Otitis media became a more frequent indication, and third-generation cephalosporin use increased.

Conclusions:

  • Public health campaigns and PCV introduction led to a significant reduction in pediatric antibiotic prescriptions.
  • Continued efforts are necessary to optimize antibiotic indications and drug selection in children.
  • Antimicrobial stewardship programs are vital for addressing antibiotic resistance.
Abstract

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