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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

Cell-based therapeutics for liver disorders.

Massoud Vosough¹, Mohsen Moslem, Behshad Pournasr

¹Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

British Medical Bulletin

|July 21, 2011

Summary

Cell therapy offers a promising alternative for end-stage liver disease, utilizing stem cells to improve patient survival. Ongoing research aims to enhance cell integration and long-term efficacy for liver disorders.

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Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

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Area of Science:

Regenerative Medicine
Hepatology
Stem Cell Biology

Background:

Limited liver donors and post-surgical complications necessitate alternative treatments for end-stage liver disease.
Cell therapy is proposed as a viable alternative to liver transplantation.

Purpose of the Study:

To review the current literature on cell-based therapies for liver disorders.
To assess the potential of cell therapy as a substitute for liver transplantation.

Main Methods:

A comprehensive literature review was conducted on cell-based therapies for liver disorders.

Main Results:

Cell therapy can improve survival rates for patients with life-threatening liver conditions.
Pluripotent stem cells show potential, pending efficient differentiation protocols and resolution of ethical/immunological concerns.
Transplanted cells currently exhibit limited integration and functionality in the recipient liver.

Conclusions:

Autologous bone marrow mononuclear cells (MNCs), hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs) have shown temporary improvements in patient conditions.
Clinical trials confirm the safety, feasibility, and efficacy of MNCs, HSCs, and MSCs for liver disorders.
Induced pluripotent stem cells and somatic cell conversion offer promising avenues for patient-specific cell therapies.