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HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges

Vineeth Thachappilly Mukundan1, Ngoc Quang Do, Anh Tuân Phan

  • 1School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore.

Nucleic Acids Research
|July 21, 2011
PubMed
Summary

The G-rich oligonucleotide T30177 forms a dimeric G-quadruplex structure in potassium solution, inhibiting HIV-1 integrase. This DNA structure features six G-tetrad layers, with thymine forming a bulge between adjacent tetrads.

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