Related Experiment Video
Updated: May 30, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Dendritic cells in bacteria handling in the gut
1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. maria.rescigno@ifom-ieo-campus.it
Abstract:
DCs in the gut have specialized functions and are involved in maintaining intestinal homeostasis via tolerizing the microbiota and inducing immunity to pathogenic bacteria. Here, we summarize the characteristics of two major subtypes of phagocytes in the gut (CX3CR1(+) and CD103(+)) and pDCs and analyze their possible involvement in bacterial handling.
Related Concept Videos
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Antigen Presenting Cells
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cell-mediated Immune Responses
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Functions of the Gut Microbiota
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

