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Updated: May 30, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
The association of current hormonal contraceptive use with type-specific HPV detection
Khalil G Ghanem1, S Deblina Datta, Elizabeth R Unger
1JHUBMC, ID Division, 4940 Eastern Ave, B3N Suite 352, Baltimore, MD 21224, USA. kghanem@jhmi.edu
Background:
Increased duration of hormonal contraceptive (HC) use may be positively associated with the risk of invasive cervical cancer.
Methods:
This is a secondary analysis from the HPV Sentinel Surveillance Study. The authors examined the association between type-specific human papillomavirus (HPV) detection and current HC use among 7718 women attending 26 sexually transmitted disease, family planning and primary care clinics in the USA.
Results:
There was an association between HC use and HPV-16 detection (adjusted prevalence rate ratio 1.34 (95% CI 1.05 to 1.71) for oral contraceptive users and 1.41 (1.01 to 2.04) for depot-medroxyprogesterone acetate users); there was no association between HC use and detection of other HPV types or any HPV overall.
Conclusions:
Longitudinal studies are needed to better define this type-specific association and its clinical significance.
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