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[Severe immune thrombocytopenia caused by interferon-beta in a patient with malignant melanoma]

Kenji Shinohara1, Naoko Kambara, Toru Takahashi

  • 1Dept. of Medicine, Towa Municipal Hospital, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 21, 2011
PubMed

A 57-year-old woman was diagnosed with malignant melanoma three years ago. She received pre- and post-operative therapy with DAV chemotherapy and Feron (Feron®, interferon-b, IFN-b). Thereafter, she received a monthly local injection of Feron®. Severe thrombocytopenia developed three years later. Immune pathogenesis was suspected since platelet-associated immunoglobulin G (PAIGg) was increased and the administration of prednisolone (PSL) quickly ameliorated the thrombocytopenia. This is the first report of severe immune thrombocytopenia caused by IFN-b. Local injections of Feron® were resumed; however, thrombocytopenia was not observed.

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