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Electrogastrography abnormalities appear early in children with diabetes type 1
Klara M Posfay-Barbe1, Keith J Lindley, Valérie M Schwitzgebel
1Department of Paediatrics, University Hospital of Geneva, Switzerland.
European Journal of Gastroenterology & Hepatology
|July 21, 2011
Summary
Gastric myoelectrical activity abnormalities, detected early in diabetic children, are linked to high blood glucose levels. These changes are not consistently found over time and do not indicate diabetic autonomic neuropathy.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Diabetic Complications
Background:
- Type 1 diabetes mellitus (T1DM) can affect gastrointestinal function, potentially leading to autonomic neuropathy.
- Gastric myoelectrical activity (GMA) assessed by electrogastrography (EGG) may reveal early functional changes in diabetic children.
Purpose of the Study:
- To evaluate GMA in children with T1DM using EGG.
- To correlate EGG findings with metabolic control (fasting glucose, HbA1c, fructosamine) and BMI.
- To assess changes in GMA over a 3-year follow-up period.
Main Methods:
- Surface electrogastrography (EGG) was performed on 49 children with T1DM and 17 age-matched controls.
- EGG parameters including bradygastria, tachygastria, and power ratio were analyzed.
- Metabolic markers (fasting glucose, HbA1c, fructosamine) and BMI were measured and correlated with EGG data.
Main Results:
- Diabetic children showed increased preprandial bradygastria and decreased normogastria compared to controls.
- The normogastric power ratio was significantly higher in diabetic children.
- Higher acute hyperglycemia correlated with postprandial bradygastria; longer diabetes duration increased EGG abnormality risk.
Conclusions:
- EGG abnormalities are present early in many diabetic children and linked to acute hyperglycemia.
- These GMA changes are not consistently observed during follow-up and are unrelated to HbA1c or fructosamine.
- Diabetic autonomic neuropathy is unlikely to be the primary cause of EGG abnormalities in this pediatric cohort.
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