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Updated: May 30, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Giant facial lymphangioma.
Claire Sanger1, Lindsey Wong, Jeyhan Wood
1Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1075, USA.
The Journal of Craniofacial Surgery
|July 21, 2011
Summary
Lymphatic malformations (LM) are benign growths from abnormal lymphatic drainage, often appearing at birth. A newborn with a giant facial LM was successfully treated with a combined approach of sclerosis, laser ablation, and surgery.
Area of Science:
- Vascular Anomalies
- Pediatric Surgery
- Dermatology
Background:
- Lymphatic malformations (LM) are congenital, benign vascular anomalies arising from aberrant lymphatic development.
- While often presenting at birth, LMs can manifest within the first two years of life.
- Facial LMs pose significant concerns due to proximity to vital structures like the airway and orbit.
Observation:
- The natural history of LMs is variable, ranging from spontaneous regression to progressive growth and functional impairment.
- Treatment decisions for LMs depend critically on their location, extent, and clinical presentation.
- Established therapeutic modalities include observation, intralesional sclerosis, laser therapy, and surgical excision.
Findings:
- A case report details a newborn infant with a giant facial lymphatic malformation.
- The infant underwent a multimodal treatment strategy.
- This approach integrated intralesional sclerosis, laser ablation, and surgical excision with reconstruction.
Implications:
- Multimodal treatment strategies can be effective for complex pediatric facial lymphatic malformations.
- Careful application of therapeutic guidelines is crucial for managing facial LMs.
- This case highlights a successful combined approach for a challenging presentation of facial lymphatic malformation.
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