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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: May 30, 2026

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

An electroactive microwell array for trapping and lysing single-bacterial cells.

Soo Hyeon Kim, Takatoki Yamamoto, Dominique Fourmy

Biomicrofluidics

|July 21, 2011

Summary

This summary is machine-generated.

Researchers developed an electrical device for high-throughput single-cell analysis. This technology effectively traps and lyses individual bacterial cells for detailed study.

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Last Updated: May 30, 2026

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Area of Science:

Biotechnology
Microfluidics
Cell Biology

Background:

Single-cell analysis is crucial for understanding cellular processes like metabolism, disease states, and adaptation.
Existing methods for single-cell analysis can be limited in throughput and efficiency.

Purpose of the Study:

To develop a novel device for high-throughput electrical trapping and lysis of single bacterial cells.
To enable detailed analysis of individual bacterial cells.

Main Methods:

Fabrication of a microwell array on a planar electrode.
Utilizing deformed electric fields to generate dielectrophoretic forces for single-cell trapping.
Applying concentrated electric potential to lyse trapped cells.

Main Results:

Successfully trapped single bacterial cells (Escherichia coli) in microwells.
Demonstrated effective lysis of individual trapped bacterial cells.
Achieved single-cell trapping through physical exclusion and dielectrophoretic force.

Conclusions:

The proposed device enables efficient electrical trapping and lysis of single bacterial cells.
This microwell array serves as a foundational tool for high-throughput single-cell bacterial analysis.
The technology has potential applications in various fields requiring individual cell characterization.