Related Experiment Video
Updated: May 30, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome
Piero Farruggia1, Alessandra Macaluso, Serena Tropia
1Pediatric Hematology and Oncology Unit, G. Di Cristina Children's Hospital, Palermo;
Abstract:
Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Pharmacokinetics in Pediatric Patients: Drug Excretion
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Nephrotic Syndrome II : Assessment and Medical Management
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Pharmacokinetics in Pediatric Patients: Drug Metabolism
