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Updated: May 30, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological

Michela Buccioni1, Gabriella Marucci, Diego Dal Ben

  • 1Medicinal Chemistry Unit, School of Pharmacy, University of Camerino, 62032, Camerino, Italy.

Purinergic Signalling
|July 21, 2011
PubMed

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G-protein Coupled Receptors

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G-protein Coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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