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Updated: May 30, 2026
05:30
Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
Published on: November 14, 2025
Necroptosis: biochemical, physiological and pathological aspects
Zsuzsanna Dunai1, Pal I Bauer, Rudolf Mihalik
1Department of Pathogenetics, National Institute of Oncology, Ráth György street 7-9, Budapest H-1122, Hungary. dunaizs@oncol.hu
Pathology Oncology Research : POR
|July 21, 2011
Summary
Necrotic cell death, previously thought accidental, can be regulated. This programmed cell death, termed necroptosis, is caspase-independent and clinically relevant in various diseases.
Area of Science:
- Cell Biology
- Pathology
Background:
- Programmed cell death is crucial for tissue homeostasis, development, and disease.
- Apoptosis is the conventional caspase-mediated programmed cell death.
- Necrosis was traditionally viewed as unregulated cell death due to extreme conditions.
Purpose of the Study:
- To introduce and define necroptosis as a regulated, caspase-independent form of programmed cell death.
- To highlight the clinical relevance of understanding necroptosis in disease.
Main Methods:
- Review of accumulating evidence on regulated cell death pathways.
- Definition of necroptosis based on its characteristics (receptor-induced, caspase-independent, regulated).
Main Results:
- Necrotic cell death can be a regulated process, distinct from apoptosis.
- Necroptosis is a programmed cell death pathway resembling necrosis morphologically.
- Necroptosis is implicated in various pathological conditions.
Conclusions:
- Necroptosis represents a significant, regulated form of cell death.
- Understanding necroptosis signaling is crucial for addressing diseases like ischemic brain injury, neurodegenerative diseases, and viral infections.
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