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[The relationship between cleft severity and incidence of associated heart defect in children with isolated cleft

Xiang-Hua Chen1, Zheng-De Tang, Ting Sun

  • 1Department of Cardiac Function, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.

Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery
|July 22, 2011
PubMed

Insights

Children with complete cleft palate have a higher risk of congenital heart defects compared to those with incomplete cleft palate. Cleft severity may predict heart issues, suggesting routine echocardiograms for all cleft palate patients.

Area of Science:

  • Medical research
  • Pediatric cardiology
  • Craniofacial anomalies

Context:

  • Cleft palate (CP) is a common congenital condition.
  • Associated congenital heart disease (CHD) is a significant comorbidity in CP.
  • Understanding the relationship between cleft severity and CHD is crucial for early detection and management.

Purpose:

  • To investigate the association between cleft palate severity and the incidence of associated heart defects.
  • To characterize the types of heart defects found in children with isolated cleft palate.
  • To determine if cleft severity can serve as a predictor for CHD in CP patients.

Summary:

  • A study of 416 children with cleft palate found that 11.1% had associated CHD.
  • The incidence of heart defects was significantly higher in the complete cleft palate group (25%) compared to the incomplete cleft palate group (9.9%).
  • Atrial septal defect was the most frequent heart malformation, accounting for 52.2% of cases.

Impact:

  • Complete cleft palate is identified as a risk factor for CHD.
  • Cleft severity emerges as a potential predictor for CHD in individuals with cleft palate.
  • The findings support the recommendation for routine echocardiograms in all cleft palate patients to screen for cardiac anomalies.
Abstract

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