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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

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Related Experiment Video

Updated: May 30, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

[Calcium and vitamins].

Ryo Okazaki1

  • 1Third Department of Medicine, Teikyo University Chiba Medical Center.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 22, 2011
PubMed
Summary
This summary is machine-generated.

Adequate calcium and vitamin D are essential for osteoporosis treatment. Eldecalcitol, a new vitamin D metabolite, and recent meta-analyses on calcium, vitamin D, and K are reviewed, addressing challenges in Japan.

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Related Experiment Videos

Last Updated: May 30, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

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Staining the Cytoplasmic Ca2+ with Fluo-4/AM in Apple Pulp

Published on: November 6, 2021

Area of Science:

  • Nutritional biochemistry and bone metabolism.
  • Pharmacology of osteoporosis treatments.

Context:

  • Osteoporosis management requires adequate calcium and vitamin D levels.
  • Vitamin D assessment and prescription face challenges in Japan, impacting treatment efficacy.
  • Review of recent meta-analyses on key nutrients for bone health.

Purpose:

  • To review recent meta-analyses concerning calcium, vitamin D metabolites, and vitamin K in osteoporosis management.
  • To discuss the role and potential of eldecalcitol, a novel vitamin D metabolite, in osteoporosis therapy.

Summary:

  • Sufficient calcium and vitamin D are foundational for effective osteoporosis pharmacotherapy.
  • Challenges in Japan, including lack of reimbursement for serum 25(OH)D measurement and restrictions on natural vitamin D prescriptions, hinder adequate vitamin D status.
  • Recent meta-analyses on calcium, vitamin D metabolites, and vitamin K are examined, alongside a discussion of eldecalcitol.

Impact:

  • Highlights the critical need for addressing vitamin D deficiency in osteoporosis patients.
  • Informs clinicians about recent evidence on nutritional interventions and novel therapeutic agents.
  • Suggests potential improvements in osteoporosis management strategies by optimizing nutrient intake and considering new drug options.