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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library
Sarah B Luesse1, Gregg Wells, Jeanne Miller
1Department of Chemistry & Biochemistry, Ohio University, Athens, Ohio 45701, USA.
Abstract:
The 7-oxabicyclo[2.2.1]heptene ring system is a common structural motif in many pharmacologically interesting molecules. We recognized the potential to employ this highly oxygenated and conformationally-restricted scaffold in diversity-oriented synthesis to generate a library of non-chiral but topologically complex compounds. Herein, we report the synthesis and biological evaluation of two 96-member tricyclic libraries containing the oxabicyclo[2.2.1]heptene framework using acetal formation as the key step.
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