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Updated: May 30, 2026
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Is the baboon model appropriate for endometriosis studies?
Jean-Paul Dehoux1, Sylvie Defrère, Jean Squifflet
1Experimental Surgery Unit, Medical School, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
Objective:
To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons.
Design:
Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection.
Setting:
Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium.
Animal(S):
Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis.
Intervention(S):
A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection.
Main Outcome Measure(S):
Follow-up by laparoscopy.
Result(S):
Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29).
Conclusion(S):
The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation.
