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Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats

Rocio Bautista-Pérez1, Abraham Arellano, Martha Franco

  • 1Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, México City, Mexico. rociobtst@yahoo.com

Diabetes Research and Clinical Practice
|July 22, 2011
PubMed

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Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...