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[Amyloidosis. Also a heart disease]
Pablo García-Pavía1, María Teresa Tomé-Esteban, Claudio Rapezzi
1Unidad de Miocardiopatías, Sección de Insuficiencia Cardiaca y Trasplante, Servicio de Cardiología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España. pablogpavia@yahoo.es
Revista Espanola De Cardiologia
|July 22, 2011
Summary
Cardiac amyloidosis occurs when amyloid proteins deposit in the heart. This review guides cardiologists on diagnosing and treating cardiac amyloidosis, a condition that may first present to them.
Area of Science:
- Cardiology
- Hematology
- Pathology
Context:
- Amyloidosis involves amyloid protein deposition in organs, notably the heart.
- Cardiac involvement can be the initial clinical manifestation of systemic or localized amyloidosis.
- Cardiologists are often the first point of contact for patients with cardiac amyloidosis.
Purpose:
- To provide a cardiologist's perspective on cardiac amyloidosis.
- To detail the diagnosis and treatment of cardiac amyloidosis.
- To review the clinical features, course, and management of various amyloidosis types affecting the heart.
Summary:
- Cardiac amyloidosis results from amyloid deposition in heart tissue, stemming from systemic or localized disease.
- Multiple proamyloid proteins can cause cardiac amyloidosis, each with distinct clinical features, progression, and management strategies.
- Early recognition and diagnosis by cardiologists are crucial for effective treatment of cardiac involvement and the underlying disease.
Impact:
- Enhances the understanding of cardiac amyloidosis for cardiologists.
- Provides a framework for timely diagnosis and tailored treatment strategies.
- Improves patient outcomes by addressing both cardiac manifestations and the primary amyloid disease.
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Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
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Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
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