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Cost analysis in laccase production.

Johann F Osma1, José L Toca-Herrera, Susana Rodríguez-Couto

  • 1Centro de Microelectrónica (CMUA), Department of Electrical and Electronics Engineering, Universidad de los Andes, Carrera 1 N° 18A - 12, Bogota, Colombia.

Journal of Environmental Management
|July 22, 2011
PubMed
Summary

Producing the enzyme laccase using solid-state fermentation (SSF) is 50 times cheaper than submerged fermentation (SmF). Further optimization in tray bioreactors reduced costs by four times, achieving a low production cost for laccase.

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Area of Science:

  • Biotechnology
  • Enzyme Production
  • Industrial Microbiology

Background:

  • Laccase is a valuable enzyme with diverse industrial applications.
  • Optimizing enzyme production costs is crucial for commercial viability.
  • White-rot fungi, like Trametes pubescens, are known for laccase production.

Purpose of the Study:

  • To determine the cost-effectiveness of laccase production by Trametes pubescens.
  • To compare the production costs between submerged fermentation (SmF) and solid-state fermentation (SSF).
  • To identify key cost-driving factors in laccase biosynthesis.

Main Methods:

  • Cultivation of Trametes pubescens using over 45 different culture media compositions.
  • Cost analysis encompassing culture medium, equipment, and operating expenses.
  • Comparative evaluation of laccase production costs under SmF and SSF conditions at flask and tray bioreactor scales.

Main Results:

  • Culture medium costs were the primary contributor to overall production expenses.
  • Equipment costs represented a minimal fraction (<2%) of the total production cost.
  • SSF significantly reduced laccase production costs by 50-fold compared to SmF at flask scale.
  • Further cost reduction of 4-fold was achieved using SSF in tray bioreactors, reaching €0.04 cent/U.

Conclusions:

  • Solid-state fermentation (SSF) offers a substantially more cost-effective method for laccase production compared to submerged fermentation (SmF).
  • Optimizing SSF in tray bioreactors further enhances economic feasibility for large-scale laccase manufacturing.
  • Culture medium composition is a critical factor influencing the overall cost of enzyme production.