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Updated: Jul 31, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
[HIV1 seropositivity and B and D viruses in West Africa]
J Soubeyrand1, E K Niamkey, S A Ouattara
1Faculté de Médecine, Service 3e Cycle, Marseille, France.
Insights
Coinfection with Hepatitis B and D viruses is common in HIV-1 positive adults in Ivory Coast. These co-infections may influence HIV-1 disease progression, suggesting B virus immunization benefits AIDS management.
Area of Science:
- Virology
- Epidemiology
- Public Health
Abstract:
This study was undertaken to investigate relationships between three widespread viruses in West Africa, i.e. HIV1 and viruses B and D, in Ivory Coast. Serologic tests for viruses B and D were carried out in a random sample of black adults of both sexes with asymptomatic HIV1 seropositivity. Coinfection by virus B or viruses B and D was a common finding. Coinfection with both viruses B and D, but not with virus B alone, was found to be significantly more frequent in these HIV1-infected adults than in a control group with acute viral hepatitis. Potential interactions between the HIV1 and viruses B and D as well as other viruses are discussed. These findings suggest that one or several cofactors acting alone or in combination play a major role in the clinical expression of HIV infection. The results of this study, together with the suggestion put forward by several investigators that B virus infection may increase the severity of AIDS, are evidence in support of the value of immunization against the B virus in the management of AIDS.
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