[Premature infants weighing less than 1000 grams: mortality, morbidity and short-term neurologic outcome]
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O Claris1, G Claris-Meunier, C Gay
1Service de pathologie et de réanimation néonatale (Pr Salle), hôpital Edouard-Herriot, Lyon, France.
Insights
Outborn premature infants (<1000g) had a significantly higher mortality rate (78%) than inborn infants (26%). Growth-retarded infants also showed better survival rates, with 70% of infants being inborn.
Area of Science:
- Neonatology
- Perinatal Medicine
- Pediatric Outcomes Research
Abstract:
The outcome of 60 premature infants weighing less than 1,000 g at birth and consecutively born during the years 1986 to 1988 is reported. Forty-two (70%) of them were inborn. The overall mortality rate was 42%, but only 26% in the inborn group instead of 78% in the outborn group (P less than 0.001). The mortality rate was higher for the appropriate for gestational age infants (56%) than for the growth retarded infants (14%, P less than 0.01). The main neonatal problems were the following: hyaline membrane disease (63%), patent ductus arteriosus (7%), bronchopulmonary dysplasia (8%), necrotizing enterocolitis (15%), intraventricular hemorrhages (45%) and periventricular leukomalacia (12%). Twenty percent (7/35) of the surviving infants showed abnormal neurodevelopmental outcome, with only one (3%) having major handicap. No correlation was found between gestational age and neuro-developmental outcome.