Related Experiment Video
Updated: May 30, 2026

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
Published on: July 11, 2025
Cognitive functioning in patients with complex absence following treatment with sodium valproate
S L Rao1, P Satischandra, M G Devi
1Shobini L. Rao, Associate Professor of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bangalore - 560 029.
Abstract:
The association of sodium valproate with cognitive functions was studied in 29 patients with complex absence seizures. Seventeen patients were on monotherapy and twelve on polypharmacy with sodium valproate. Cognitive functions assessed were attention, speech, visuo-speciat perception, memory and intelligence. Behavioral disturbances were also assessed. Two assessments were made six months apart; in the first assessment, attention and speech were adequate, while memory, visuo-spatial perception, and behavioral functioning were impaired. Intelligence was lower in the polypharmacy group, while other functions were similar. In the second assessment, intelligence and visual memory improved in the monotherapy group, while no changes were present in the polypharmacy group.
Related Concept Videos
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Hepatic Encephalopathy
