Related Experiment Video
Updated: May 30, 2026

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
Published on: June 28, 2024
Cardiac output assessed by invasive and minimally invasive techniques
Allison J Lee1, Jennifer Hochman Cohn, J Sudharma Ranasinghe
1Jackson Memorial Hospital, University of Miami, Miami, FL 33136, USA.
Abstract:
Cardiac output (CO) measurement has long been considered essential to the assessment and guidance of therapeutic decisions in critically ill patients and for patients undergoing certain high-risk surgeries. Despite controversies, complications and inherent errors in measurement, pulmonary artery catheter (PAC) continuous and intermittent bolus techniques of CO measurement continue to be the gold standard. Newer techniques provide less invasive alternatives; however, currently available monitors are unable to provide central circulation pressures or true mixed venous saturations. Esophageal Doppler and pulse contour monitors can predict fluid responsiveness and have been shown to decrease postoperative morbidity. Many minimally invasive techniques continue to suffer from decreased accuracy and reliability under periods of hemodynamic instability, and so few have reached the level of interchangeability with the PAC.
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