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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Mucosal immunity and Candida albicans infection
David L Moyes1, Julian R Naglik
1Department of Oral Immunology, King's College London Dental Institute, King's College London, Floor 28, Tower Wing, London SE1 9RT, UK.
Clinical & Developmental Immunology
|July 22, 2011
Summary
Host mucosal surfaces distinguish between beneficial and harmful microbes, crucial for health and disease. Understanding these interactions, particularly with Candida albicans, aids in developing treatments for various conditions.
Area of Science:
- Immunology
- Microbiology
- Cell Biology
Background:
- Mucosal surfaces interact with a high density of microbes, necessitating mechanisms to differentiate between commensals and pathogens.
- Epithelial cells and novel immune cell subsets, like T helper 17 (T(h)17) cells, play critical roles in host defense and microbial recognition.
Purpose of the Study:
- To review current knowledge on the interactions between the opportunistic fungus Candida albicans and host epithelial surfaces.
- To elucidate the mechanisms underlying mucosal-microbial discrimination and its implications for host defense and disease.
Main Methods:
- Literature review of existing studies on host-microbe interactions at mucosal surfaces.
- Analysis of research focusing on epithelial cell responses and immune cell subsets, specifically T(h)17 cells.
- Examination of interactions between Candida albicans and epithelial cells.
Main Results:
- Recent research highlights the significant role of epithelial cells and T(h)17 cells in microbial discrimination.
- Studies involving Candida albicans provide valuable insights into the complexities of mucosal-microbial interactions.
- Understanding these interactions is essential for comprehending host defense and disease pathogenesis.
Conclusions:
- Elucidating the mechanisms of mucosal-microbial interactions improves understanding of host defense against pathogens like Candida albicans.
- This knowledge is vital for developing strategies to treat diseases associated with microbial dysbiosis.
- Further research into these interactions promises advancements in managing various health conditions.
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