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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

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Articles linked to this work by shared authors, journal, and citation graph.

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Correction to: Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2020
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Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2019
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Clinical and Histopathological Assessment on an Animal Model with Experimental Autoimmune Encephalomyelitis.

Current health sciences journal·2019
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Applications of inflammation-derived gingival stem cells for testing the biocompatibility of dental restorative biomaterials.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2018
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Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial.

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Factors that influence the severity of post-stroke depression.

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Related Experiment Video

Updated: May 30, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Plasmatic markers in hemorrhagic stroke.

I C Marginean1, D M Stanca, V Vacaras

  • 1Department of Neurology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Journal of Medicine and Life
|July 22, 2011
PubMed
Summary
This summary is machine-generated.

Early stroke diagnosis is crucial. Researchers are evaluating blood tests using biomarkers like GFAP and NMDA to improve stroke detection and risk assessment, aiding faster treatment.

Keywords:
biomarkerdiagnosishemorrhagic strokeischemic strokestroke

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Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Diagnostics

Background:

  • Stroke is a leading cause of death and disability in the US.
  • Timely diagnosis and intervention are critical for reducing brain damage and mortality.
  • A rapid, cost-effective blood test could significantly aid stroke management.

Purpose of the Study:

  • To explore the potential of various biological markers for early stroke diagnosis.
  • To assess the utility of these markers in risk stratification for stroke patients.
  • To identify promising biomarkers for future large-scale validation studies.

Main Methods:

  • Review and analysis of existing research on potential stroke biomarkers.
  • Identification of molecules tested for their diagnostic and prognostic value in stroke.
  • Consideration of technological requirements for a practical clinical blood test.

Main Results:

  • Several molecules, including Glial Fibrillary Acidic Protein (GFAP) and N-methyl-D-aspartate receptor (NMDA), show promise as stroke biomarkers.
  • Other potential markers include APO C-III, APO C-I, PARK7, NDKA, S100B, and growth factors.
  • Limitations include the correlation between disability and tissue loss, and blood-brain barrier effects on protein release.

Conclusions:

  • Certain biological markers show potential for improving acute stroke diagnosis and risk stratification.
  • Further large-scale studies are necessary to validate these findings and establish their clinical utility.
  • The development of a simple, low-cost blood test based on these markers could revolutionize stroke care.