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Erk in kidney diseases

Denis Feliers1, Balakuntalam S Kasinath

  • 1Division of Nephrology, Department of Medicine, O'Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, TX 78229, USA.

Journal of Signal Transduction
|July 22, 2011
PubMed

Insights

Kidney injury involves repair mechanisms initiated by circulating factors. This review focuses on the extracellular signal-regulated kinase (ERK) pathway

Area of Science:

  • Nephrology
  • Molecular Biology
  • Cell Signaling

Background:

  • Kidney injury, both acute and chronic, arises from diverse insults.
  • Compensatory repair mechanisms are activated following kidney injury.
  • Circulating factors initiate injury and repair, mediated by signal transduction pathways.

Purpose of the Study:

  • To review the role of the mitogen-activated protein kinase (MAPK) cascade in kidney injury and repair.
  • To specifically elucidate the function of the extracellular signal-regulated kinase (ERK) cascade in renal injury and recovery.

Main Methods:

  • Literature review focusing on signal transduction pathways in kidney injury.
  • Analysis of the phosphatidylinositol 3' kinase (PI-3K)/mammalian target of rapamycin (mTOR) and MAPK cascades.
  • Detailed examination of the extracellular signal-regulated kinase (ERK) pathway's involvement.

Main Results:

  • Two primary signal transduction pathways, PI-3K/mTOR and MAPK, are activated during kidney injury and repair.
  • The ERK cascade, a component of the MAPK pathway, plays a significant role in these renal processes.

Conclusions:

  • The ERK cascade is a key player in the cellular responses to kidney injury.
  • Understanding ERK signaling is crucial for developing therapeutic strategies for kidney repair.

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