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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
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Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Making carbon nanotubes biocompatible and biodegradable.

Alberto Bianco1, Kostas Kostarelos, Maurizio Prato

  • 1CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, Strasbourg, 67000, France. a.bianco@ibmc-cnrs.unistra.fr

Chemical Communications (Cambridge, England)
|July 22, 2011
PubMed
Summary

Functionalized carbon nanotubes show promise in nanomedicine. Recent findings reveal these nanomaterials are biodegradable by oxidative enzymes, paving the way for safer clinical applications.

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Fabrication, Densification, and Replica Molding of 3D Carbon Nanotube Microstructures

Published on: July 2, 2012

Area of Science:

  • Nanomedicine
  • Biomaterials Science
  • Toxicology

Background:

  • Carbon nanotubes (CNTs) are versatile nanomaterials with significant potential in nanomedicine for diagnostics and therapeutics.
  • Current research focuses on enhancing CNT biocompatibility and mitigating toxicity for medical applications.
  • A key challenge for clinical translation of CNTs is their perceived non-biodegradability.

Purpose of the Study:

  • To highlight recent advances in developing biocompatible and biodegradable functionalized carbon nanotubes (f-CNTs).
  • To address the skepticism surrounding CNTs' biodegradability in medical contexts.
  • To explore the potential for translating these improved CNTs into clinical practice.

Main Methods:

  • Review of recent scientific literature on functionalized carbon nanotube development.
  • Analysis of studies demonstrating the enzymatic degradation of functionalized carbon nanotubes.
  • Evaluation of strategies for improving CNT biocompatibility and biodegradability.

Main Results:

  • Chemically functionalized CNTs exhibit reduced toxicity compared to pristine CNTs.
  • Recent evidence shows that functionalized CNTs can be degraded by oxidative enzymes.
  • This enzymatic degradation offers a new perspective on CNT safety and applicability in medicine.

Conclusions:

  • The biodegradability of functionalized carbon nanotubes by oxidative enzymes represents a paradigm shift.
  • This breakthrough facilitates the design of safer CNTs for nanomedical applications.
  • Further development and research can accelerate the clinical translation of biocompatible and biodegradable CNTs.